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Missouri Department of Health & Senior Services says they're seeing a huge spike in the number of cases of explosive diarrhea across the state this week.

A new look at think tank discussions of nuclear war scenarios now includes 5 Illinois targets that would likely be a part of a first strike and one is a surprise.

See the 5 Missouri lakes that most people don't know about, but are more than worth discovering.

There are 5 corridors in Illinois that have become hotspots for cargo theft.

St. Louis has landed on a new list for the least safe cities to drive in across America.

A new video reveals what it's like inside a Springfield, Missouri underground home that withstood an EF-4 twister.

There's a recent map and list that shows flock cameras are being used by law enforcement in every part of Missouri and the number is growing quickly.

See how to avoid a new text scam that nearly fooled a Missouri deputy that claims to originate from a real bank.

Three people in separate cars all saw the same huge black cat near Callao, Missouri — and nobody's quite sure what to call it.

There's been a sudden uptick of seismic activity along the New Madrid Fault in southern Missouri with a swarm of 9 quakes over just the past few days that nearly no one noticed.

There are many roads, highways and interstates in Missouri that travelers dread the most during the summer months.

Rainforest Cafe once had 59 locations in the U.S. Now, there are only these 16 restaurants.

Someone stopped at this Eolia, Missouri gas station on July 8 and walked out with a winning $50,000 lottery ticket.

Some areas in southern Missouri are dealing with flash flood emergencies after storms dumped up to 11 inches of rain overnight.

There are 5 Missouri locations that now appear on a list of most likely first-strike targets if an enemy were to launch a surprise first-strike nuclear war.

The FBI is asking for help in solving the cold case mystery of two Illinois sisters who disappeared on July 6, 2001.

Charter Communications has announced it plans to close a network operations facility in Town and Country, Missouri in September and 107 workers jobs will be impacted.

There's a shark attack warning map that includes Missouri that's being passed around, but there's some real history behind the humor.

Hundreds in Illinois felt an earthquake centered under Lake Michigan today.

Multiple sources are warning that a derecho pattern is forming that could bring volatile thunderstorm development to both Missouri and Illinois.

Online rumors claim a data center is coming to Canton, Missouri. Here's why they're not true.

There are two locations in Missouri that were impacted by asteroids and there might be a third.

There are 10 types of wildlife you're most likely to encounter in Illinois.

Miley revealed the details behind her very own Barbie and what it means to her.

A Missouri bank is closing 9 branches that will impact 66 workers including many at their Missouri headquarters.

A recent crackdown by Illinois State Police on the interstates resulted in 61 vehicles being taken out of service.

Looking for the best BBQ in Illinois? Guy Fieri's favorite Chicago barbecue restaurant continues drawing fans from across the country.