Alex Smith threw for 145 yards and two touchdowns, and ran for 78 yards and a touchdown to lead the Kansas City Chiefs over the Detroit Lions 45-10 Sunday at Wembley Stadium.

Smith scrambled his way through the Detroit defense for some big plays, including a career-high 49-yard run in the second quarter that set up his 12-yard touchdown run.

The Chiefs (3-5) were playing at Wembley for the first time, while the Lions (1-7) played in London for the second straight season.

De'Anthony Thomas, Charcandrick West and Spencer Ware also rushed for touchdowns for the Chiefs. Thomas ended up with 100 total yards, while West ran for 97. Travis Kelce and Jeremy Maclin caught TD passes in the second half.

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